Synthesis, Characterization and Studying the Anti-Fungal Activity of Resveratrol-Oxadiazole Derivatives
Ph.D, Department of biomedical engineering, Al-Esraa University College, Baghdad, Iraq
Ph.D, pharmaceutical chemistry, Department of pharmacy, Al-Esraa University College, Baghdad, Iraq
MSC, pharmaceutical chemistry, Department of pharmacy, Al-Rafidain University College, Baghdad, Iraq
This study concerns with the antimicrobial properties of resveratrol-oxadiazole derivatives, with special emphasis on its antifungal activity linked oxadiazole 5-member aromatic heterocyclic compound which exhibits antifungal activity. The introduction of oxadiazole ring into target compounds effectively enhancing their bioactivity as antifungal. Resveratrol derivatives containing 1,3,4 oxadiazole ring had been synthesized and characterized successfully and their antifungal activity was estimated and showed that they have antifungal activity against C. albicans. The study results demonstrated that Compound 2 and 3 showed good activity against C. albicans when compared with resveratrol the positive control and DMSO the negative control, that the antifungal activity here is due to the synthesized compound and not to the solvent used, these compounds gave different inhibition zones at different concentration( 0.05 mcg/ml, 0.025 mcg/ml, 0.01 mcg/ml, 0.005 mcg/ml) and this seemed to be beneficial as antifungal since they gave inhibition zone at even very low concentration 0.005 mcg/ml higher than parent compound. while compound 1 had the least inhibition zones among them. These compounds can be further investigated with other types of fungi and compared with different types of standard as antifungal agents.