History of Medicine


An Open Access Journal

A study of the protective effect of 5 Thiocyanatouracil against paracetamol overdose in rats

Ibtihal J. Naoor
Department of Pharmacology, College of Medicine, University of Basrah, Iraq.
Nadheerah F. Neamah
Department of Toxicology, College of Pharmacy, University of Basrah, Iraq.
Jawad K. Hasan
Department of Pharmacology, College of Medicine, University of Basrah, Iraq.


A new chemical called 5-Thiocyanauracil (TCU) has been created and is being studied for its potential hepatoprotective, anti-inflammatory, and antioxidant effects. Against paracetamol (PA) overdose oxidative stress in female rats. The study's goal was to investigate data that TCU's protective properties against liver and kidney impairment brought on by PA in rats. Fifty female-rats were employed, classify to five groups; 10 rats each: Control group (C) received 2 ml distal water (DW). Group (PA) take 500 mg/kg/day of PA, TCU group received 50 mg/kg/day, while PA & TCU group, administered TCU 50 mg/kg/day followed by 500 mg PA. Last group is combination of PA &AA (ascorbic acid) at 50 mg /kg /day. The treatments were used orally for 25 days. Blood samples were drowning from the hearts of rats directly. The samples of liver and kidney were collected for histopathological investigation. Liver and kidney function tests were evaluated by an auto-analyzer. TCU treatment reduced total protein (TP) levels in serum, decreased alkaline phosphatase enzyme (ALP), aspartate aminotransferase enzyme (AST), alanine transaminase (ALT), and total bilirubin (TB) levels in liver tissue as compared to rats given PA. TCU treated rats showed normal liver cell structure without damage, and reduced infiltration of neutrophil. Such result proposes the ability to reduce inflammation by PA high dose and reduce tendency of the liver cell to cause necrosis. There is no effect in kidney function and its histology. In conclusion that TCU played a potential hepatoprotective action in liver damage related to PA in rats.

Keywords: 5 thiocyanaturacil; Paracetamol, liver function test, renal function test, renal histopathology, liver histopathology. ,


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