History

Background: Captopril aqueous solution that prepared using drug as a powder dissolved in water was stable only for approximately twenty seven days. The aim of the present work was conducted with preparing captopril as stable dry solid effervescent granules that form suitable swallowing aqueous liquid dosage for pediatric. Methods: Six formulas were, formulated, by two different procedures: the wet method; and; the fusion method, using citric acid, tartaric acid and potassium hydroxide as the effervescent base at different ratios. The evaluation of granules was done for their flowability concerning tapped density, bulk density, angle of repose, in addition to measuring the pH, Carr’s; index, effervescent time, particle size, drug content and in vitro; study of dissolution. Results: F2, that prepared by wet granulation method at a ratio of 1:2:4.8 consisting of citric acid, tartaric; acid, with; potassium hydroxide respectively. F2 was; chosen as a selected formula according to its accepted flow property, good distribution of particle size, and drug content of 97.5%. In addition to a fast effervescence time of 48.44 sec. and 100% drug release within 2 min. Conclusion: Captopril was successfully prepared as effervescent granules especially by wet granulation technique.