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Synthesis and Biological Activity Evaluation of Some 1-(4-Hydroxy-3-Methoxyphenyl) Ethan-1-One Derivatives.

Entidhar Thajeel Mankhi
Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar,64001, Iraq
Athraa Hameed Mekky
Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar,64001, Iraq

Abstract

This study consist of synthesized of some of 1-(4-hydroxy-3-methoxyphenyl)ethan-1-one derivatives, firstly, the derivatives E1-E5 have been synthesized by the reaction of the alkyl halide 1-bromopropane , 1-chlorobutane, 1,5-dibromo pentane, 1-bromo pentane and 1,4-dichloro butane respectively with 1-(4-hydroxy-3-methoxyphenyl) ethan-1-one in the presence of a catalyst of potassium carbonate ,The structures of the prepared compounds were confirmed by the different available spectroscopic methods, such as FTIR, 1H-NMR and 13C-NMR and mass spectroscopy. The physical properties were assessed. Biological activities of some synthesized derivatives were investigated.

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