History

A robust T cell response can lead to milder infections. It can also establish memory pools and can respond to certain SARS-CoV-2 variants. T cells are mainly directed toward epitopes that are part of conserved peptides. Although the effects of IL2 and IFN on long-term immunity are still unclear, it is believed that these two factors play a role in the development of TH1 responses in uninfected individuals. By analyzing the responses of the participants, we were able to determine that 9 out of the 11 individuals exhibited dual-producing IFN/IL-2+ T cells, decreasing to 8 out of 10 for the asymptomatic group. The reduction in the levels of IL2 in TH1type cells, which came from asymptomatic infection, has made it possible to predict the response of T cells to IFN in people with no previous history of infection or vaccination. After the first vaccination, the not-vaccinated participants had a high level of IL-2 response. Compared to AstraZeneca's vaccine, the Pfizer vaccine was more likely to elicit a higher L2 response. On the other hand, the IFN response of the AstraZeneca vaccine was not significantly different from that of the Pfizer vaccine.