History

The current study aimed to estimate vitamin D concentration and some physiological variables in patients with beta thalassemia. 150 subjects with thalassemia were taken from both Azadi Teaching Hospital and Al Jumhuri Hospital from November 2021 to April 2022. The experimental work was carried out in private laboratories in Kirkuk, Iraq. The volunteers in the current study were divided as follows: 50 healthy volunteers as a control group. 150 thalassemia patients as a second group. The results showed that the activity of liver enzymes showed a significant increase (P < 0.05) in thalassemia patients with beta thalassemia compared to the control group. the ferritin and D dimer concentrations showed a significant increase (P < 0.05) in patients compared to the control group. For oxidative stress, malondialdehyde (MDA) level showed a significant increase (P < 0.05) in patients compared to the control group. The glutathione (GSH), catalase and superoxide dismutase (SOD) concentration showed a significant decrease (P < 0.05) in the patients (0.284 ± 0.025) compared to the control group. the concentration of vitamin D showed a significant decrease (P < 0.05) in patients compared to the control group. It is concluded from the current study that there is a link between thalassemia and liver enzymes, and this indicates the direct effect of beta-thalassemia on the liver. On the other hand, it was found that both ferritin and D dimer can be considered as indicators for the detection of thalassemia. The results of the current study also showed that there is an association between vitamin D deficiency and beta thalassemia.