History

Recent research has shown that the SNP of the rs2910164G>Cgene, as well as the most prevalent genotype and allele frequency, can be used to determine the co-morbidity of UTI with RA. Seventy-five people with RA and eighty people with urinary tract infections (UTIs) were included in this case-control research. Genotyping of the rs2910164GC gene polymorphisms by allele specific polymerase chain reaction was performed. In RA patients the Genotypes (GC, CC) of rs2910164G>C gene polymorphism displayed a significant association (P≤0.05) in comparison with the control group and allele C rs2910164G>Cgene had a high ratio in RA (54.9 %) in comparison with the control group (45.1%). These findings confirmed the association between the rs2910164 G>C polymorphism and RA susceptibility. In addition, the rs2910164 G>C C allele was found to be associated with increased risk for RA. (OR, 0.66; 95% CI, 0.417-1.057; P=0.084). In UTI patients genotypes of this gene (GG, GC, CC) rs2910164G>Cgene polymorphism displayed a non-significant association (P≤0.05) in comparison with the control group. allele G had a high ratio in UTI (77.33%) rs2910164 G>C gene was non-significant risk factor for predisposition of UTI patients to cause RA by recurrent infection. Furthermore, the rs2910164 G>C C allele was identified as non-risk factor for susceptibility to RA in UTI (OR, 1.595; 95% CI, 0.961-2.649; P=0.070) .