Green Synthesis of Mn3O4 Nanoparticles using chia seeds extract, characterization, and cytotoxicity on the HL-60 cells
Department of Chemistry, College of Education for Pure Science, University of Diyala, Iraq
Department of Chemistry, College of Education for Pure Science, University of Diyala, Iraq
Abstract
In medicine, nanoparticles are successfully replacing anticancer drugs (NPs). In this study, Mn3O4-NPs were made using the green chemistry Chia seed extract method, and they were then characterized using various methods, including FTIR, XRD, EDX, and SEM. HL-60 cells were tested against Mn3O4 nanoparticles at varied concentrations (20, 40, 80, and 160 µg/ml), with an average size of 35.27 nm in the XRD. After 24 hours, the killing rate was 4%, 14%, 24%, and 40% in that sequence. Moreover, the rates were (4%, 26%, 44%, and 40%) in that sequence after 48 hours. Half-maximal inhibitory concentrations (IC50) for Mn3O4 -NPs are 220.5 at 24 hours and 97.83 at 48 hours. Mn3O4 nanoparticles offer potential therapeutic advantages as anticancer drugs. The drug was safe at all concentrations (not harmful).
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