History

Nanotechnology-based antibiotic synthesis is one of the most crucial contemporary strategies for preventing antibiotic resistance. ZnONPs particles were produced using the chemical precipitation process and mixed with Amoxicillin using the physical method with ultrasonic equipment to create nano antibiotics. The Amoxicillin particle matrix was discovered to have a steady dispersion of AMOX nanoparticles. Using XRD, EDX, and SEM techniques, the resulting nanocomposites were examined for their characteristics and contrasted with those listed in the ICDD database [ICDD card no. 41-0254]. ZnONPs had an average crystal size of 40.37 nm, whereas AMOX loaded with ZnONPs had an average crystal size of 39.21 nm. The bacterial activity of AMOX bound with ZnONPs was examined. By measuring the lowest inhibitory concentration of one type of bacteria using an ELISA technique, it was compared to regular Amoxicillin particles. AMOX bound with ZnONPs shows good bactericidal activity against Staphylococcus. MIC was 256 µg/ml. In contrast, the MIC of typical AMOX was 1024 µg/ml, demonstrating that the aforementioned substance was more efficient than common Amoxicillin. AMOX loaded with ZnONPs was also tested for toxicity through hemolysis. The findings of the trials showed that the chemicals were safe at all concentrations.