History

Entamoeba histolytica is a parasitic pathogenic protozoan that causes amebiasis in humans. Evidence suggests that combined oral contraceptives (COCs) influence parasitic infection development and progression, as well as host susceptibility to infection and the resulting differences in immune response. The experiment was carried out on 50 female white mice, 10 of which were healthy (control negative) and 40 of which were infected with E.histolytica. The results were shows accumulation of lipid, dilation of sinusoid, increase inflammatory cell infiltration, slightly increase kupffer cells in liver and hyperplasia of Goblet cell with Lymphoid tissue hyperplasia in intestine .In this research shown the virulence of COC on liver and intestine of the infected mice