Association of Heat Shock Protein 90B1 (HSP 90B1) with Immunopathogenesis of Poly Cystic Ovarian Syndrome
University of Karbala, College of Medicine, Medical Microbiology Department, Karbala/Iraq,
University of Karbala, College of Medicine, Medical Microbiology Department, Karbala/Iraq,
University of Karbala, College of Medicine, Medical Microbiology Department, Karbala/Iraq,
Karbala gynecological and obstetric teaching hospital, Karbala/Iraq
Abstract
Polycystic ovary syndrome (PCOS) Among the chronic endocrinopathies that most commonly afflict women in the reproductive age range. Hirsutism, acne, irregular menstrual cycles, or obesity are frequent perimenarchal stage presenting symptoms. Granulosa cells (GCs) are crucial for the maturation, fertilization, and subsequent implantation of oocytes. A stress-inducible chaperone protein is HSP90B1. Many researches revealed that increased levels of Hsp90b1 which is an anti-apoptotic protein might be involved in the pathogenesis of PCOS. The study aimed to evaluate HSP90B1 in serum and estimate its correlation with demographic characteristics. 130 women, 66 patients with PCOS, and 64 regarded as control had estimated their serum levels of HSP 90B1, the mean levels were 5.41 in patients and 4.47 in control. The HSP 90B1 showed a positive association with the immunopathogenesis of PCOS.
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