Estimation of Interleukin 17A Gene Polymorphism in Patients with Polycystic Ovary Syndrome
College of Medicine, University of Karbala, Karbala, Iraq
College of Medicine, University of Karbala, Karbala, Iraq
College of Medicine, University of Kufa, Najaf, Iraq,
Al-sader Teaching Hospital, AL-Zahraa Teaching Hospital, Najaf, Iraq
Abstract
Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with a vital genetic component and is characterized by polycystic ovaries, hyperandrogenemia, and menstrual irregularity. Methods: A case-control study includes 50 PCOS-affected women and 50 healthy women as a control group. Whole blood was used for DNA extraction. DNA extraction was used to detect Interleukin-17A gene polymorphism (rs2275913) usingReal-Time Polymerase Chain Reaction (RT-PCR). Results: Regarding the genotypes of IL-17A gene (rs2275913) polymorphism, there were no significant differences between the studied group (P=0.421).The AG genotype was at a higher frequency in patients compared with control (50% vs. 42%, respectively); also, the AA genotype was elevated in patients compared with control (16% vs. 12%, respectively).In the alleles frequency, there were no significant differences between the studied group (P=0.307). Conclusion:The result of this study has shown that the IL-17A gene (rs2275913) polymorphism maybe have a protective role in PCOS.Further studies are requiredto demonstrate the role of this polymorphism in PCOS disease.
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