History

Background: Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) poses major threat worldwide contributing to excessive morbidity and mortality, these co-morbidities synergistically interact with inflammatory mechanisms. The study aimed to observe levels the Amylin, Creatine phospho kinase (CPK), Total cholesterol (TC), Triglycerides (TG), High density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL). Also to evaluate correlation between (Amylin, CPK, TC, TG, HDL, LDL and VLDL). Methods: Serum Amylin, CPK, TC, TG, HDL, LDL and VLDL levels were determined in 50 patients with acute myocardial infraction, 50 patients with (type 2 diabetes with myocardial infraction) and 50 healthy subjects. Results: The results show a significant increase in the concentration of serum (amylin, CPK, TC, TG, LDL and VLDL) in (T2DM with AMI) group in comparison with the (AMI and controls) groups (p≤0.05). But it was found no significant deference in the concentration of serum amylin between (AMI and controls) groups (p≤0.05). Also it was found no significant deference in the concentration of serum CPK between (T2DM with AMI and AMI) groups (p≤0.05). While it was found a significant decrease in the concentration of serum HDL in (T2DM with AMI) group in comparison with the (AMI and controls) groups (p≤0.05). It was found a positive correlation between serum amylin and ( CPK, TC, TG, LDL and VLDL) and a negative correlation between serum amylin and HDL. Conclusion: We finding a positive correlation between amylin and (CPK, TC, TG, LDL and VLDL). Also we finding negative correlation between amylin and HDL.