History of Medicine


An Open Access Journal

Correlation of Arginine Vasopressin coding gene and Human High Blood Pressure

Aseel Isam AL-Nuri
Assistant Lecturer in Biology Department, Education College for Girls, University of Mosul/ Mosul, Iraq
Dr. Sarab Daoud AL-Shamaa
Assistant Professor in Biology Department, College of Science, University of Mosul, Mosul/ Iraq.


Arginine vasopressin (AVP) is a Peptide synthesized in the hypothalamus and transported via axons to the posterior part of the pituitary gland that regulates the arteries' High blood pressure, Then released to the blood when needed. A study design data were collected from the Al-Salam teaching hospital and the Ibn-Sena teaching hospital in Mosul as blood samples during the period 1/2/2022 to 1/9/2022. To perform a hormonal study and molecular study, (5ml) of blood was taken. The number of purposive samples is (160) samples taken from males only; aged less than 20 years to 50 years and above had been utilized in this study. The control group included 60 healthy individuals, the unhealthy group was divided into (40) patients without treatment, and (60) patients which have treatment. The serum concentration of this hormone had been measured and it was between (20.7-34.2 ng), Significantly decreased at (p< 0.05) in all groups except in those aged 50 years and above compared with the control group had been determined. Besides the Amplicon copy numbers of AVP coding genes were very low in all patient groups compared with the control is considered an important indicator of gene activities utilizing Real-time-PCR technique. These results concluded that this hormone had an important correlation with hypertension.

Keywords: Hypertension, Arginine vasopressin, Amplicon, AVP coding gene. ,


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