History

Background: Insulin resistance is an impairment of insulin biological action with reduction in muscle and adipose tissue sensitivity to insulin level resulting in decreased glucose uptake in the muscle and increased glucose production from liver causing hyperglycemia in both the fasting and postprandial states. Worldwide, the prevalence of insulin resistance varies between 15.5% to 46.5% among adults. Objectives: The present study was conducted with the objective to determine the relationship between insulin resistance and Body mass index ,waist circumference , residency and alcohol consumption among apparently healthy Shekhan medical students. Materials and Methods: The study was carried out as across sectional study among 200 Shekhan medical students ranging from 18- 39 years old who were randomly selected from the student population. Under strict aseptic precautions blood samples was collected from all the participants, the serum was investigated for glucose, insulin, and lipid parameters (cholesterol, triglyceride, HDL-C, LDL-CH). Insulin resistance was determined using (HOMA-IR). Results: The prevalence of insulin resistance was 21.50% among Shekhan medical students. The mean homeostatic model assessment was higher in those married, older than 25years, overweight and obese. The mean BMI and WC were significantly higher in those with HOMA IR >3.0 as well as the majority of those with IR were leaving in urban area. Moreover, there was a positive and significant correlation of insulin resistance with BMI, WC and residency (P < 0.05). Conclusion: Prevalence of insulin resistance among the Shekhan medical students was high ranging about 21.50% especially obese female leaving in urban area.