History

The current study the effect of urine and serum cystatin in diabetic nephropathy patients in Najaf. This investigation was carried out at the Al-Sadr Teaching Hospital in Najaf's Diabetes and Endocrine Center for a period from May 2022 to October 2022. the study included 42 males with diabetic type 2 ranging in age from 30 to 62. they were divided into 3 groups intended UACR and were divided, into two groups depending on Egfr and evaluated serum and urine cystatin C, HbA1C, creatinine, urea, UACR, Egfr, lipid profile, CRP. The result of the current study according to albuminuria showed no significance in age, duration of diabetes, BMI, cholesterol, HDL, VLDL, while this study registered significance (p<0.05) in HbA1C, UACR, Serum CR, eGFR, urea, TG, CRP, serum cystatin and urine cystatin. So, when comparing eGFR stages were found higher significance(p<0.001) in UACR, eGFR, and (p<0.05) serum CR, Urea, TG, CRP, serum cystatin, and urine cystatin. ROC for cystatin C was 0.703 and ROC for urine cystatin was 0.802. The negative relationship between eGFR and urine cystatin C levels, serum cystatin C levels and (serum creatinine) {R = - 0.438, p = 0.003}, {R = - 0.416 , p = 0.010 }, { R = - 0.557, p = 0.009}. in conclusion Urine and serum cystatin maybe use a marker besides creatinine to diagnose early kidney dysfunction.