History

Objective: The present study was designed to identify the effect of CD19+ B-cells in Hemodialysis (HD) patients compared to healthy volunteers and, also investigates its relationship with essential parameters parathyroid hormone (PTH), vitamin D3 (VitD3). Methods: A total of (60) clinically diagnosed patients and (30) healthy group, were collected from /February 2022 to July 2022/. Information was collected through a questionnaire designed for the present study. The serum levels of CD19 were evaluated using ELISA and serum remains were collected, for PTH and D3. Results: The result of the present study showed that the mean serum CD19 levels was significantly decreased (P < 0.001) in patients compared to healthy volunteers. Although the level of PTH was significantly higher (P < 0.001) in HD patients, the results showed a significant decrease in levels of D3 (P < 0.001). Furthermore, there was a highly significant positive correlation between B-cells levels and vitamin D3 level as well as showed this study a highly significant negative correlation between B-cells and PTH. Conclusion: Chronic kidney disease (CKD)-associated immunodeficiency has been associated with a decrease in B cells, and a substantial proportion of morbidity and mortality with advanced conditions; therefore, we can support the immune system of HD patients before deterioration. In future studies, a monthly examination of the CD19 + correlations with laboratory parameters may improve outcomes and disease. Also verifying the primary immune source that affects the disturbance of the natural system of the kidney, more studies are needed to shed light on therapies with antibodies.