History

Objective: Hypocholesterolemia is a metabolic disorder that can occur in malignancies. Distinct dyslipidemia profiles have been demonstrated in adult and pediatric hematologic malignancies. The aim of this study to assess the lipid profile of patients diagnosed with chronic lymphocytic leukemia. Methods: We assessed lipid profile of Fifty-one patients with chronic lymphocytic leukemia were attended two hematology laboratory facilities of hospital in Erbil and Duhok governorates. Wherever, total cholesterol, triglyceride (TG) values, Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL) were analyzed. For statistical analysis, the student’s t-test and the One-way ANOVA test were utilized. In order to do the statistical analysis, SPSS version 26 was used. 95% confidence intervals and a significance threshold of p 0.05 were used to analyze the results. Results: Total cholesterol, LDL and HDL levels were significantly lower in the study group in conjunction with the progression of the disease stages (p<0.01). Conclusion: Hypocholesterolemia and low LDL and HDL levels can occur in chronic lymphocytic leukemia. It should be borne in mind that malignancies may be the etiology of unexpected hypocholesterolemia and hypertriglyceridemia. The impact of dyslipidemia on the pathogenesis and prognosis of chronic lymphocytic leukemia requires further study.