History of Medicine


An Open Access Journal

Assessment of Serum Vitamin D in Transfusion-Dependent Β-Thalassemia Patients: Single-Center Observational Study

Ghazi Mohamad Ramadan
Ahlulbayt University College, Karbala, Iraq.
Samer Raheem Obaid
Ministry of Health, Babylon Health Directorate, Iraq.
Hussein Ali Abdulabbas
College of Nursing, University of Babylon, Iraq
Hayder Abdul-Amir Makki Al-Hindy
Ph.D., Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon, Iraq


Background: Earlier surveys found that thalassemic patients on repeated blood transfusions unveiled substantial falls in vitamin D concentrations. This observational study aimed to assess vitamin D status among transfusion-dependent β-thalassemia major patients in Babylon City.Materials and methods: This is a single-center observational study comprising 304 patients with β-thalassemia major (184 males and 120 females) aged between 2.3-17.9 years. The next records were taken from all candidates: demographic features, age at first diagnosis, socioeconomic state, family history, residency, frequency of blood transfusions per month, types of chelating therapy; and laboratory examinations of serum vitamin D and ferritin. The statistical inspection had finished using the SPSS software version23. The qualitative parameters had stated as count +/- percentage, whereas the quantitative parameters had expressed as means +/- SD. A P-value of less than or equal to 5% reflected a significant value.Results: The mean ages of the patients were 12.8 ± 9.9 years, with the predominant male sex (60.5%), and around 2/3rd of them lived in rural areas and (62.1%) have a positive family history of thalassemia among the siblings. The main finding was a high frequency of hypovitaminosis D among thalassemia subjects (40.4%). As well, there was a nonsignificant association between the serum vitamin D levels and ferritin (P-0.3, r-0.11), a highly-significant negative association between vitamin D levels and the ages (P-0.3, r –0.3), and a highly-significant positive association between levels of ferritin and the ages (P-0.006, r-0.2) among the thalassemia patients.Conclusions: Our results suggest a high incidence of hypovitaminosis D among thalassemia subjects with a non-significant correlation between serum vitamin D levels and ferritin. As well, there was a highly significant correlation between ferritin levels and age among the thalassemia patients.

Keywords: Thalassemia, Iron overload, Ferritin, Vitamin D. ,


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I.M. Sechenov

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