Evaluation of Anti-Oxidant Potential and Novel Synergism Effect of Citrullus colocynthis against MDR pathogenic Strains
Abstract
Citrullus colocynthis belong to family Cucurbitaceae is a medicinal plant traditionally used for the treatment of various diseases [1][2] including diabetes, bacterial infections, constipation and many other diseases. Various parts of plant individually produced anti-microbial and anti-oxidant potential. This is the first study reporting 1. The Novel synergism effect of Citrullus colocynthis, Fruit, Seed and root extract against MDR pathogenic strains in the least concentration of various organic solvents extracted compounds (first study reporting anti-microbial activity of Butanol extracted compounds) 2. Inhibitory concentration (IC50) of these compounds against MDR 3. Novel Synergism of C. colocynthis fruit, seed and root showing anti-oxidant potential. According to findings, Citrullus colocynthis can be used as medicinal plant as its various compounds isolated through organic solvents showed antimicrobial activity against MDR-pathogens. Maximum activity against MDR pathogens of Pseudomonas Aeurignosa, Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Stenotrophomonas maltophilia, Salmonella typhi, Salmonella paratyphi, Acinetobacter baumanni and Enterococcus faecalis was shown by Butanol extract followed by Chloroform, Acetone, Ethanol, Hexane and DMSO extract. The plant also showed 92% anti-oxidant potential in the least concentration of 93µg/mL.
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- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
