STRUCTURAL DOCKING OF ANTIBIOTIC ENTECAVIR FOR THE TREATMENT OF PEDIATRIC ACUTE LIVER FAILURE BY USING DISCOVERY STUDIO
DOI:
https://doi.org/10.48047/HM.V11.I2.2025.21-37Abstract
This research specifically focused on children who have experienced acute liver failure in the field of pediatric liver transplantation (LT). Acute liver failure in children is a complex, life-threatening illness that can either go away on its own or result in death. LT is a procedure that can save lives. Standby list mortality has decreased, as has overall prognosis, graft survival, and immunosuppression survival due to the development of technical variant grafts and subsequent immunosuppressive adjustments. Acute liver failure (ALF) is a syndrome with a variety of underlying causes, such as renal, cardiac, pulmonary, and hepatic encephalopathy, which causes a rapid loss of hepatic function. The pathophysiology of ALF, including hepatocyte necrosis, extrahepatic consequences, and hepatocyte regeneration, is significantly influenced by hepatic and circulating inflammatory cytokines. Unchecked cytokine overproduction is dangerous to the host and can have negative effects. Hepatocyte-specific injury is caused by the activation of the innate and adaptive immune systems, and T regulatory cell activity reduces this damage. The integrated stress response (ISR; e.g., PERK), p53, and HNF4 are examples of apoptotic and regenerative pathways that must be activated for the native liver to recover. Recurrent ALF is brought on by loss-offunction mutations in these pathways in response to non-hepatotropic viruses.
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Copyright (c) 2025 Ali Raza Nawab, Amina Aroo, Sana Ghaffar, Mian Zahid Sarfraz, Syeda Warda Bukhari (Author)
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